Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis

Neonatal intestinal dysbiosis in necrotizing enterocolitis

Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiology occurs in the hyper-reactive milieu of the premature gut after bacterial colonization. The resultant activation of the TLR4 pathway appears to be a strongly contributing factor. Advanc...

Ischaemic enterocolitis Infarction of the intestinal tract Intestinal gangrene Haemorrhagic enterocolitis Neonatal necrotizing enterocolitis Uraemic enterocolitis

A supply of oxygenated blood appropriate to the tissue needs of the gut is essential to the maintenance of its vital functions. The splanchnic vascular system serves this purpose and much of our knowledge of ischaemic bowel disease has developed from studies of radiological and pathological abnormalities of this system. The purpose of this paper is to summarize current information concerning th...

Alpha-lipoic acid attenuates trinitrobenzene sulfonic acid-induced ulcerative colitis in mice.

Ulcerative colitis (UC), characterized by inflammation, oxidative stress, and increased intestinal epithelial cell apoptosis, is an immunologically mediated chronic intestinal disorder. The present study was aimed at investigating the protective effects of alpha-lipoic acid (ALA) against trinitrobenzene sulfonic acid (TNBS)-induced UC and the underlying mechanism. ALA of 80 mg/kg bw/day was adm...

Protective effect of royal jelly in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in rats

Objective(s):In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Materials and Methods: Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that received only saline solution, a TNBS-induced colitis group, and a TNBS-co...

Neonatal Necrotizing Enterocolitis